Dr. Shrestha Sinha Ray earned her doctoral degree from University of Florida in Microbiology
and Cell Science. Her Ph.D. thesis focused on understanding the evolution of bacterial
genetics and biofilms.
Owing to her passion in cell and molecular biology, she then conducted her postdoctoral
training at the Center for Gene Therapy at Nationwide Children's Hospital on in-vitro
modelling of neurological diseases and developing therapeutics using vector-based
gene delivery. She has taught various courses on molecular biology at Ohio State University.
Thus, she gained both research and teaching skills in cell, molecular biology and
neuroscience.
Her current research interests focus on developing cell culture models for rare neurological
diseases and testing of different drugs as therapeutics.
Sierra A, Sinha-Ray S,Kaleem A, ParvateMi, et al. In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related
Disorders (2023). Biology 12 (6).
Sinha-Ray S, Dutta Debdeep, Dennys Cassandra, et al, Mechanisms of IRF2BPL related disorders and a potential treatment strategy (2022).
Cell Reports, 41, 111751. (first author)
Federica P, Alexander S, Niran M, Rim D, Adolfo O, Priyanka T, Alfred Y, Olivier S, Angelina O, Cassandra N D, Shrestha SR, et al. PolyGA targets the ER stress-adaptive response by impairing GRP75 function
at the MAM in C9ORF72-ALS/FTD (2022). Acta Neuropathol 144 (5).
Marcogliese PC, Dutta D, Ray SS et al. Loss of IRF2BPLimpairs neuronal maintenance through excess Wnt signaling (2022).
Science Advances 8(3):eabl5613.
Dennys CN, JA Sierra-Delgado, Ray SS et al. In vitro modeling for neurological diseases using direct conversion from fibroblasts to neuronal progenitor cells and differentiation into
astrocytes (2021). JOVE ;172 (e62016).
Sinha-Ray S, Alam TM, S Bag, Morris JG, Marco S, Ali A. Conversion of a recA-Mediated Non-toxigenic Vibrio cholerae O1 Strain to a Toxigenic Strain Using Chitin-Induced Transformation (2019). Frontiers in Microbiology;10 (2562). (first author)
Sinha-Ray S, & Ali A. Mutation in flrA and mshA Genes of Vibrio cholerae Inversely Involved in
vpsIndependent BiofilmDriving Bacterium Toward Nutrients in Lake Water (2017). Frontiers in Microbiology ;8(1770). (first author)
Alam MT, Ray SS, Chun CN, Chowdhury ZG, Rashid MH, Madsen Beau De Rochars VE, et al. Major Shift
of Toxigenic V. cholerae O1 from Ogawato Inaba SerotypeIsolated from Clinicaland Environmental Samplesin Haiti
(2016). PLoS Neglected TropicalDiseases;10(10):e0005045.
Azarian T, Ali A, Johnson JA, Jubair M, Cella E, Ciccozzi M, Nolan JD,Farmerie W,
Rashid MH, Ray SS, et al. Non-toxigenic Environmental Vibrio cholerae O1 Strain from Haiti Provides Evidence of Pre-Pandemic Cholera in Hispaniola (2016).
Scientific Reports;6:36115.
Vuppu S, Mishra B, Gopinath R, Ray SS, Gaurav K., Chaubey P, Chaudhri A, Rath K. Screening and Identification of Degradable
Productsby Pectin LyaseProducing Actinomycetes from Katpadi and Chittoor fruitIndustrialwaste Enriched Soil Samples (2012). AJMBES;14(3):405.
N Jain, R Gupta, RK Rai, SS Ray, V Sharma. Anti-microbial activity of TiO2 microparticles in suspension on E. coli strains under
UV irradiation (2012). J. Pharm. Biol. Sci;1, 21-30.
